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Stay away from or substitute A further drug for these drugs when possible. Examine for loss of therapeutic effect if medication have to be coadministered. Modify dose In keeping with prescribing info if needed.
Adjunct use, if apprehension, nervousness or acute tension reactions existing just before endoscopic processes
diazepam will improve the stage or result of tazemetostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
cannabidiol will increase the amount or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Intently. Consider reducing the dose of sensitive CYP2C19 substrates, as clinically suitable, when coadministered with cannabidiol.
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Concomitant utilization of benzodiazepines, such as diazepam, and opioids could bring about profound sedation, respiratory depression, coma, and Loss of life; reserve concomitant prescribing of benzodiazepines and opioids to be used in patients for whom substitute procedure alternatives are insufficient; decrease opiate dose just one-3rd when diazepam is additional
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Coadministration of other CNS depressants or Alcoholic beverages use may well potentiate CNS-depressant consequences of diazepam
Drugs that have quantity limits linked to Each individual prescription. This restriction usually boundaries the amount of the drug which will be protected.
mitotane decreases amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane is a strong inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for doable dosage changes.
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Cessation of benzodiazepines or other CNS depressants is most well-liked in most cases. In some cases, checking at an increased standard of care for tapering CNS depressants may be acceptable. In Some others, steadily tapering a affected person off of the prescribed benzodiazepine or other CNS depressant or reducing to the bottom successful dose may be acceptable.